AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Caffeine half life neonate11/11/2023 ![]() ![]() provided additional data on the pharmacokinetic profile of caffeine citrate using doses of 5 to 20 mg per kg in a dose finding study that highlighted the accumulation of caffeine 5. This target plasma concentration was based on similar plasma concentrations of theophylline being effective for bronchodilation to reverse airway obstruction in adults with asthma and toxicity observed at plasma concentrations above 20 mg per L 4. ![]() The authors noted their goal was to maintain a plasma concentration in the range of 5 to 20 mg per L. Based on this data, the dosing for subsequent infants in the study was changed to a 20 mg per kg intravenous loading dose of caffeine citrate followed by a maintenance dose of 5 to 10 mg.kg −1 once or twice per day started 2 to 3 days after the loading dose. Following this, plasma caffeine concentrations of 50 to 60 mg per L were obtained and a prolonged elimination of caffeine was noted. In this study, infants were initially administered a dose of 20 mg.kg −1 of caffeine citrate once or twice daily by mouth. In this study, 18 preterm infants with apnea were administered caffeine citrate and a marked reduction in apnea spells was observed from a mean of 14 per 24 hours before caffeine treatment to 2 per 24 hours following treatment. ![]() published the first study of caffeine used to treat apnea of prematurity 3. In 1973, Kuzemko and Paala reported on improvement in apnea among 10 preterm infants after the administration of 5 mg aminophylline suppositories 2. A. History and Evolution of “Standard Dose” Caffeine ![]()
0 Comments
Read More
Leave a Reply. |